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(-)-dihydrotanshinone I, (1R)-1,6-Dimethyl-1,2-dihydrophenanthro(1,2-b)furan-10,11-dione, 15,16-dihydrotanshinone I, 15,16-dihydrotanshinone-I, dihydrotanshinone I, dihydrotanshinone-I

No.	Title	Href
1	Dihydrotanshinone exerts antitumor effects and improves the effects of cisplatin in anaplastic thyroid cancer cells. Oncol Rep. 2021 Sep;46(3):204. doi: 10.3892/or.2021.8155.	`Click`

No.

Title

Href

Dihydrotanshinone exerts antitumor effects and improves the effects of cisplatin in anaplastic thyroid cancer cells. Oncol Rep. 2021 Sep;46(3):204. doi: 10.3892/or.2021.8155.

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Name	Dihydrotanshinone I
PubChem CID	11425923
Molecular Weight	278.3g/mol
Synonyms	(-)-dihydrotanshinone I, (1R)-1,6-Dimethyl-1,2-dihydrophenanthro(1,2-b)furan-10,11-dione, 15,16-dihydrotanshinone I, 15,16-dihydrotanshinone-I, dihydrotanshinone I, dihydrotanshinone-I
Formula	C₁₈H₁₄O₃
SMILES	CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C=CC=C43)C
InChI	1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
InChIKey	HARGZZNYNSYSGJ-JTQLQIEISA-N
CAS Number	87205-99-0
ChEMBL ID	CHEMBL227075
ChEBI ID	CHEBI:149872
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	ZiDanCan
Use Part	Root
Habitat	AnHui, ShanXi, HeBei, SiChuan, JiangSu, HuBei, GanSu, LiaoNing, Shaanxi, ShanDong, ZheJiang, HeNan, JiangXi
Flavor	Bitter
Meridian Tropism	Heart, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia miltiorrhiza

Chineses Pinyin	FuPenZi
Use Part	Aggregate Fruit
Habitat	AnHui, JiangSu, ZheJiang
Flavor	Sweet, Sour
Meridian Tropism	Liver, Kidney, Bladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Rosaceae 　　　　　-->Genus: Rubus 　　　　　　-->Species: Rubus chingii

Chineses Pinyin	GanXiShuWeiCao
Use Part	Root
Habitat	GanSu, SiChuan, YunNan, Shaanxi, GanSu, QingHai, NingXia, XinJiang, XiZang
Flavor	Bitter, Pungent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia przewalskii

Chineses Pinyin	HongGenCao
Use Part	Whole Herb With Root
Habitat	JiangSu, AnHui, ZheJiang, JiangXi, HuNan, GuangDong, GuangXi
Flavor	Bitter, Mildly pungent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia prionitis

Chineses Pinyin	HuangHuaShuWeiCao
Use Part	Root
Habitat	SiChuan, YunNan
Flavor	Bitter

Chineses Pinyin	JiYeShuWeiCao
Use Part	Flower, Leaf
Habitat	YunNan
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia bulleyana

Chineses Pinyin	LiSeShuWeiCao
Use Part	Root
Habitat	YunNan
Flavor	Pungent
Meridian Tropism	Liver, Kidney, Heart
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia castanea

Chineses Pinyin	MaoDiHuangShuWeiCao
Use Part	Root
Habitat	YunNan
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia digitaloides

Chineses Pinyin	NaDanShen
Use Part	Root
Habitat	ZheJiang, JiangXi, FuJian, HuNan, GuangDong, GuangXi
Flavor	Bitter
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia bowleyana

Chineses Pinyin	NiDanShen
Habitat	ZheJiang, AnHui, HuBei
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia sinica

Chineses Pinyin	SanYeShuWeiCao
Use Part	Root
Habitat	YunNan
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia trijuga

Chineses Pinyin	YunNanShuWeiCao
Use Part	Root
Habitat	YunNan, SiChuan, GuiZhou, XiZang, ChongQing
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia yunnanensis

Chineses Pinyin	ZiTengZi
Use Part	Seed
Habitat	BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuNan, HuBei, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, LiaoNing, Shaanxi, GanSu
Flavor	Sweet
Meridian Tropism	Liver, Stomach, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Wisteria 　　　　　　-->Species: Wisteria sinensis

Chineses Pinyin	DanShen
Use Part	Root
Habitat	GanSu, SiChuan, GuiZhou
Flavor	Bitter
Meridian Tropism	Heart; Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Salvia 　　　　　　-->Species: Salvia miltiorrhiza

Pair Name	Dihydrotanshinone I, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2D10.Z]	Thyroid cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	MAD2L1	hsa4085
	Up-regulation	Expression	PARP1	hsa142
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	SW1736	Thyroid gland anaplastic carcinoma	Homo sapiens (Human)	CVCL_3883
In Vitro Model	8505C	Thyroid gland anaplastic carcinoma	Homo sapiens (Human)	CVCL_1054
Result	The present study is the first to demonstrate that DHT exerts antitumor effects on ATC cells by reducing MAD2 expression levels. Moreover, a synergistic effect of DHT with cisplatin was shown. Further in vivo studies are required to assess this phytochemical compound as a potential adjuvant for the treatment of ATC.